The Role of Histone Deacetylases in GlucoseMetabolism: a Mini- Review
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چکیده
Histone deacetylases (HDACs) and histone acetyltransferases (HATs) maintain the balance of histone acetylation, and play important role in chromosome modification and gene expression. Histone deacetylases have been identified to modify acetylation of proteins other than histones and inhibit gene expression. Here we summarize the functions of histone deacetylases in glycometabolism including the expression of histone deacetylases in different energy conditions, effects of histone deacetylases on islet development, glucose uptake in skeletal muscle, hepatic gluconeogenesis as well as the role of histone deacetylases inhibitors in glycometabolism. Modulation of histone deacetylases provides an alternative opportunity of a therapy for both type 1 and type 2 diabetes.
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